1. Constipation and the Microbiome: Lumen Versus Mucosa!
Eamonn M.M. Quigley 
Gastroenterology 
Volume 150, Issue 2, Pages (February 2016)
DOI: /j.gastro
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2. Figure 1
Interactions between diet, the microbiota and colonic physiology in the pathogenesis of constipation. (1) Bile acids entering the colon are deconjugated and stimulate both motility and secretion; a deficiency of bile acids could promote constipation. (2) Dietary fiber and other poorly absorbed carbohydrates are metabolized to produce short chain fatty acids, which promote net fluid absorption and may also enhance motility. In individuals with a methanogenic microbiota, methane is produced, which has been shown to slow transit. (3) Changes in the mucosal or juxtamucosal microbiota could promote constipation by enhancing absorption. Red arrows indicate impacts of products of interactions between the colonic microbiota and luminal contents on colonic functions (luminal pH, mucosal absorption/secretion, colonic motility). Dashed arrows indicate effects that are proposed but not necessarily universally accepted.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2016 AGA Institute Terms and Conditions