1. I. Fluorescence Enhance
Enhanced PC fluorescence by the gold nanorod surface plasma and its function in curing cancer cells
Lei Li, Ji-Yao Chen
During the past few years photodynamic therapy (PDT) has become a noninvasive treatment modality for a range of diseases including cancers.[1-4] Aluminium tetrasulfonated phthalocyanine (AlTSPc) is a nontoxic PDT drug, which is FDA approved for clinical trials against tumors.[5] But the time of entering cancer cells for the AlTSPC is a little long, and also its fluorescence isn’t strong enough for us to detect. The gold nanorod will help us to work out the problems.
I. Fluorescence Enhance
Connnected with gold nanorod, the fluorescence of AlTSPc has enhanged five times than before.
II. Enter cells
Connected with gold nanorods, AlTSPc enters cells more easily
Reflected images, AlTSPc connected with gold nanorods even in cells
III. MTT Results
Cell Cytotoxicity assay,
giving them more exposure time,
PDT can kill more cells.
IV. Conclusions
The hexadecyl trimethyl ammonium bromide(CTAB) covered gold nanorod makes the nanorod dissolve in the water, and also the gold nanorod get positive charge on its surface. Because of the negative charge on the AlTSPc, we can connect the AlTSPc with the gold nanorod forming AlTSPc-CTAB-gold nanorod. The new drug enter the cells much more quickly than the AlTSPc does and the fluorescence intensity is much more higher than the AlTSPc.
References:
(1) Henderson, B. W.; Dougherty, T. J. Photochem. Photobiol. 1992, 55, 145–157.
(2) Sharman, W. M.; Allen, C. M.; van Lier, J. E. Drug Discovery Today 1999, 4,507–517.