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Human uterine and ovarian expression of growth hormone–releasing hormone messenger RNA in benign and malignant gynecologic conditions  Omid Khorram, M.D.,

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Presentation on theme: "Human uterine and ovarian expression of growth hormone–releasing hormone messenger RNA in benign and malignant gynecologic conditions  Omid Khorram, M.D.,"— Presentation transcript:

1 Human uterine and ovarian expression of growth hormone–releasing hormone messenger RNA in benign and malignant gynecologic conditions  Omid Khorram, M.D., Ph.D., Mark Garthwaite, B.S., Elizabeth Grosen, M.D., Ted Golos, Ph.D.  Fertility and Sterility  Volume 75, Issue 1, Pages (January 2001) DOI: /S (00)

2 Figure 1 (A), A gel demonstrating expression of growth hormone–releasing hormone (GHRH) messenger RNA in various human reproductive tissues as determined by reverse transcription polymerase chain reaction. (B), Quantification of GHRH bands (Panel A) in various reproductive tissues as described in methods. Khorram. GHRH mRNA in the ovary and uterus. Fertil Steril 2001. Fertility and Sterility  , DOI: ( /S (00) )

3 Figure 2 Endometrial expression of growth hormone–releasing hormone (GHRH) messenger RNA in the proliferative (8 patients) and secretory phase (8 patients) of the menstrual cycle. ∗P<.05 compared with proliferative phase. Khorram. GHRH mRNA in the ovary and uterus. Fertil Steril 2001. Fertility and Sterility  , DOI: ( /S (00) )

4 Figure 3 (A), A gel demonstrating GHRH mRNA in normal ovarian tissue, metastatic ovarian cancer implants, endometriomas, and the ovarian cancer cell lines OVCAR-3 and SKOV-3. (B), Quantification of the GHRH bands of normal and ovarian endometriotic tissue. (C), Quantification of the GHRH bands of normal and ovarian cancer implant. ∗∗P<.01 compared with normal tissue. Khorram. GHRH mRNA in the ovary and uterus. Fertil Steril 2001. Fertility and Sterility  , DOI: ( /S (00) )


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