1. Volume 79, Issue 5, Pages 546-554 (March 2011)
Oncostatin M receptor β and cysteine/histidine-rich 1 are biomarkers of the response to erythropoietin in hemodialysis patients 
Michael L. Merchant, Adam E. Gaweda, Andrew J. Dailey, Daniel W. Wilkey, Xiaolan Zhang, Brad H. Rovin, Jon B. Klein, Michael E. Brier 
Kidney International 
Volume 79, Issue 5, Pages (March 2011)
DOI: /ki
Copyright © 2011 International Society of Nephrology Terms and Conditions

2. Figure 1
Plot of serum C-reactive protein (CRP) and hepcidin from subjects displayed according to group and gender. Mean values are displayed where the vertical line and middle horizontal line intersect. The upper and lower horizontal lines represent the s.d.
Kidney International  , DOI: ( /ki )
Copyright © 2011 International Society of Nephrology Terms and Conditions

3. Figure 2
Plot of serum interleukin (IL)-6, IL-7, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) from subjects displayed according to group and gender. Mean values are displayed where the vertical line and middle horizontal line intersect. The upper and lower horizontal lines represent the s.d.
Kidney International  , DOI: ( /ki )
Copyright © 2011 International Society of Nephrology Terms and Conditions

4. Figure 3
Graphic comparison of the change in peptide abundance in good- to poor-responder serum samples with the corresponding statistical significance P-value for each peptide. The t-test and ratio data are plotted using log–log graphing for each significant peptide from the freely soluble serum peptide (a) and protein-bound serum peptide (b) fractions. The shaded region denotes masses with a P-value < When possible, the parent protein for each protein fragment is annotated with the appropriate protein accession number. In some cases, multiple peptides originated from the sample protein and result in the multiple annotations of the same gene accession number. CO3, complement C3; CYHR1, cysteine and histidine-rich protein 1; FGA, fibrinogen α chain; FGB, fibrinogen/fibrinopeptide B; F13A coagulation factor XIII chain A.
Kidney International  , DOI: ( /ki )
Copyright © 2011 International Society of Nephrology Terms and Conditions

5. Figure 4
Distribution of serum oncostatin M receptor β (OSMRβ) fragments and protein levels associated with erythropoietic-stimulating agent (ESA) responsiveness. Peptide abundance data were extracted from aligned mass spectrometry (MS) data sets and peptide spectral abundance was calculated from the MS ion cluster area.10 For purposes of illustration, peptides not observed in particular samples were assigned non-zero background abundance values arbitrarily equal to 10. Vertical scatter plots (mean±s.e.m.) for the differences in serum abundance for (a–c) three OSMRβ fragments and for (d, e) densitometry measurements of circulating OSMRβ illustrate significant differences in abundance between good-response (GR) and poor-response (PR) groups.
Kidney International  , DOI: ( /ki )
Copyright © 2011 International Society of Nephrology Terms and Conditions

6. Figure 5
Distribution of serum cysteine/histidine rich 1 (CYHR1) fragment and protein levels associated with erythropoietic-stimulating agent (ESA) responsiveness. Peptide abundance data were extracted from aligned mass spectrometry (MS) data sets and peptide spectral abundance was calculated from the MS ion cluster area. Vertical scatter plots (mean±s.e.m.) for the differences in serum abundance for (a) one CYHR1 fragment and for (b, c) densitometry measurements of circulating oncostatin M receptor β (OSMRβ) illustrate significant differences in abundance between good-response (GR) and poor-response (PR) groups. (d) The specificity of the CYHR1 antibody was confirmed using immunogen competition experiments where primary antibody was preincubated with tenfold excess of synthetic immunogen before applying to a freshly blotted and blocked membrane.
Kidney International  , DOI: ( /ki )
Copyright © 2011 International Society of Nephrology Terms and Conditions