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Unravelling Spinal Circuits of Pain and Mechanical Allodynia

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Presentation on theme: "Unravelling Spinal Circuits of Pain and Mechanical Allodynia"— Presentation transcript:

1 Unravelling Spinal Circuits of Pain and Mechanical Allodynia
Vijayan Gangadharan, Rohini Kuner  Neuron  Volume 87, Issue 4, Pages (August 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 The Conundrum of Allodynia
Top: How do pathways mediating tactile sensation and pain interact to produce allodynia? Bottom: A model of circuits mediating mechanically evoked pain and mechanical allodynia, based on results reported in Peirs et al., 2015 and Duan et al., PN, projection neurons; V, vertical cells; VGLUT3, vesicular glutamate transporter type 3; SOM, somatostatin; EX, excitatory neuron; IN, inhibitory neuron; Dyn, dynorphin; PKCγ, protein kinase C γ; CR, calretinin. Neuron  , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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