1. Volume 18, Issue 8, Pages 955-965 (August 2011)
Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus 
John W. Phillips, Michael A. Goetz, Scott K. Smith, Deborah L. Zink, Jon Polishook, Russell Onishi, Scott Salowe, Judyann Wiltsie, John Allocco, Janet Sigmund, Karen Dorso, Suzy Lee, Stephen Skwish, Mercedes de la Cruz, Jesús Martín, Francisca Vicente, Olga Genilloud, Jun Lu, Ronald E. Painter, Katherine Young, Karen Overbye, Robert G.K. Donald, Sheo B. Singh 
Chemistry & Biology 
Volume 18, Issue 8, Pages (August 2011)
DOI: /j.chembiol
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2. Chemistry & Biology 2011 18, 955-965DOI: (10. 1016/j. chembiol. 2011
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3. Figure 1
Two-Dimensional Cluster Analysis of S. aureus Fitness Test Profiles for the Crude Extract, Kibdelomycin, and Four Compounds of Known Mechanism of Action
Strain depletions are depicted in magenta, strain resistances in cyan. The thresholds for including strains in the cluster analysis are >5-fold depletion, p-value ≤ 0.01 in at least 4 of the experiments for any one compound or extract. The compound name is followed by the treatment concentration. Profiles for the Crude Extract and Kibdelomycin cluster tightly with profiles of the antibiotic Novobiocin. The antisense strains targeting the 2 subunits of DNA gyrase (gyrA, gyrB) and DNA topoisomerase IV (parC, parE) are shown in red.
Chemistry & Biology  , DOI: ( /j.chembiol )
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4. Figure 2 Chemical Structure of Kibdelomycin
Chemistry & Biology  , DOI: ( /j.chembiol )
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5. Figure 3 Inhibition of Macromolecular Synthesis of Kibdelomycin
Inhibitory effects across increasing concentrations were determined by measuring incorporation of radiolabeled precursors of either DNA (14C-thymidine), RNA (3H-uridine), phospholipid (2-3H-glycerol), protein (3H-leucine), or cell wall (14C-glycine) in S. aureus strain EP167.
Chemistry & Biology  , DOI: ( /j.chembiol )
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