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Effects of SC144 on in vivo ovarian tumor.

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Presentation on theme: "Effects of SC144 on in vivo ovarian tumor."— Presentation transcript:

1 Effects of SC144 on in vivo ovarian tumor.
Effects of SC144 on in vivo ovarian tumor. A, SC144 treatment reduced tumor blood vessels in OVCAR-8 xenograft mice. Top left, tumors excised from i.p. vehicle-treated and SC144-treated mice are shown. Bottom, immunohistochemical staining for CD31. Percentage of positively stained areas was determined by the number of areas of stained microvessels divided by number of nuclei. Bar, SEM. **, P < B, SC144 (i.p.) treatment induced extensive areas of necrosis in OVCAR-8 xenograft mice. Three different fields were used for quantification of areas of necrosis. Bar, SEM. ***, P < C, immunohistochemical staining of TUNEL and Ki67. Percentage was determined by the number of double-stained cells divided by the number of nuclei. Bar, SEM. **, P < 0.01; ***, P < D, SC144 (i.p.) treatment downregulated gp130/Stat3-mediated gene expression in OVCAR-8 tumors from xenograft mice. Shili Xu et al. Mol Cancer Ther 2013;12: ©2013 by American Association for Cancer Research

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