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The cerebellum:
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Cerebellum: Principally a motor organ Responsible for:
Regulation and control of muscle tone Coordination of movement, especially skilled, voluntary movement Control of posture and gait
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Motoric movements: Willed: Cortical. Pyramidal motor system
Automatic: Static, postural. An expression of the extrapyramidal motor system Coordination of willed movements
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Extrapyramidal system:
Cerebellum Basal ganglia
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Cerebellum: None of the motor activities of the cerebellum reach conscious kinesthetic perception: It`s main role is to assist in the initiation and modulation of willed movements that are generated in the cerebral hemispheres
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3 Parts: Flocculonodular lobe. Oldest portion. Archicerebellum.
Afferent fibers = proprioceptive impulses from vestibular nuclei. Equilibrium. Vestibulocerebellum
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Anterior lobe: Paleocerebellum Spinocerebellum
Proprioceptive fibers from muscles and tendons. Dorsal spinocerebellar tract (lower limbs) and ventral spinocerebellar tract (upper limbs). Maintains posture and muscle tone.
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Posterior lobe: Neocerebellum
Afferent fibers from cerebral cortex via the pontine nuclei and brachium pontis. Pontocerebellum Coordination of skilled movements that are initiated at a cerebral cortical level
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Clinical signs in cerebellar disease:
Hypotonia Ataxia, Nystagmus Incoordination Disorders of equilibrium and gait
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Basal ganglia:
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Anatomic considerations:
No precise definition Caudate nucleus + Lentiform nucleus with it`s 2 subdivisions: Putamen Globus Pallidum
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Physiology: “Brake and switch” theory
The basal ganglia function as a brake or switch The tonic inhibitory (brake) action of the basal ganglia prevent their target structures from generating unwanted motor activity Switch function: Refers to the capacity of the basal ganglia to select which motor program will be active at any given time
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Other theories: “Motor programming”:
Role of the basal ganglia in the initiation, sequencing and modulation of motor activity.
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Several motor syndromes:
Loss of voluntary movement with spasticity: Corticospinal tract involvement Incoordination: Cerebellum Involuntary movements—dystonia: Basal ganglia
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Symptoms of basal ganglia disease:
Motor disorders: Deficits = negative symptoms or, Involuntary movements = positive symptoms (effects)
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Negative: Bradykinesia, akinesia, loss of postural reflexes.
Positive: Tremor, rigidity, involuntary movements—dystonia, chorea etc..
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