1. p53 and Metabolism: The GAMT Connection
Yan Zhu, Carol Prives 
Molecular Cell 
Volume 36, Issue 3, Pages (November 2009)
DOI: /j.molcel
Copyright © 2009 Elsevier Inc. Terms and Conditions

2. Figure 1
The Multiple Functions of p53 in Metabolic Stress and Creatine Metabolism
The p53 tumor suppressor protein not only coordinates multiple functions including the ability to promote cell-cycle arrest, apoptosis, and senescence through its target genes such as p21, PUMA, BAX, etc., but also through its targets DRAM, SCO2, and TIGAR, which regulate metabolic pathways controlling autophagy, mitochondrial respiration, and glycolysis, respectively. Identification of GAMT as a new p53 target connects p53 to the creatine metabolism pathway that was previously shown to involve creatine kinase. The involvement of GAMT/creatine in both genotoxic and metabolic stress-mediated apoptosis as well as the requirement of p53-dependent upregulation of GAMT in glucose deprivation-induced FAO implicate a critical role of p53 in coordinating stress response with changes in cellular metabolism.
Molecular Cell  , DOI: ( /j.molcel )
Copyright © 2009 Elsevier Inc. Terms and Conditions