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Adriana K. Burlá, Núbia S. Lobato, Zuleica B

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Presentation on theme: "Adriana K. Burlá, Núbia S. Lobato, Zuleica B"— Presentation transcript:

1 Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats 
Adriana K. Burlá, Núbia S. Lobato, Zuleica B. Fortes, Wille Oigman, Mario Fritsch Neves  International Journal of Cardiology  Volume 165, Issue 3, Pages (May 2013) DOI: /j.ijcard Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Systolic blood pressure (BP) (A), plasma glucose (B), plasma insulin (C) and Homeostasis Model Assessment (HOMA-IR) (D) in all groups. Results are presented as mean±SEM. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Representative images of optical microscopy showing interstitial (upper images) and perivascular (lower images) collagen density in all groups. Increased media-to-lumen ratio of intramyocardial arterioles may also be observed in MSG groups. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions


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