1. Volume 117, Issue 5, Pages 1147-1154 (November 1999)
Activation of the GABAB receptor inhibits transient lower esophageal sphincter relaxations in dogs 
Anders Lehmann, Madeleine Antonsson, Marianne Bremner-Danielsen, Maria Flärdh, Lena Hansson-Brändén, Lillevi Kärrberg 
Gastroenterology 
Volume 117, Issue 5, Pages (November 1999)
DOI: /S (99)
Copyright © 1999 American Gastroenterological Association Terms and Conditions

2. Fig. 1
Dose-response relationship for baclofen (IV and IG) with respect to (A) inhibition of TLESRs and (B) effects of baclofen given IV on intragastric pressure. ED50 for inhibition of TLESRs was 1.0 μmol/kg (95% confidence interval, 0.33–3.23) for the IV route and 1.8 μmol/kg (95% confidence interval, 0.93–3.59) for the IG route. ANOVA showed that the dose dependency was statistically significant (P = for IV route and for IG route). Results are means ± SEM; n = 4–5 (IV, solid line) or 3–6 (IG, dashed line). Intragastric pressure was only consistently increased after the highest dose of baclofen (*P < 0.05; **P < 0.01).
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

3. Fig. 1
Dose-response relationship for baclofen (IV and IG) with respect to (A) inhibition of TLESRs and (B) effects of baclofen given IV on intragastric pressure. ED50 for inhibition of TLESRs was 1.0 μmol/kg (95% confidence interval, 0.33–3.23) for the IV route and 1.8 μmol/kg (95% confidence interval, 0.93–3.59) for the IG route. ANOVA showed that the dose dependency was statistically significant (P = for IV route and for IG route). Results are means ± SEM; n = 4–5 (IV, solid line) or 3–6 (IG, dashed line). Intragastric pressure was only consistently increased after the highest dose of baclofen (*P < 0.05; **P < 0.01).
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

4. Fig. 2
Comparison of the effects on motility parameters of 1.4 μmol/kg of R-baclofen (■) with a 5-fold higher dose of S-baclofen (7 μmol/kg; □). Statistically significant difference between the effects of R- and S-baclofen was only achieved with regard to (A) inhibition of TLESRs, although there was a clear tendency for a difference in terms of (B) latency (note that there was no change from control levels after administration of S-baclofen). Results are means ± SEM; n = 6 in each group. ***P < (R- vs. S-baclofen). Control absolute values are given in Table 1.
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

5. Fig. 3
Effects of CGP36742 (70 μmol/kg IV) on motility parameters in the presence or absence of baclofen (1.4 and 7 μmol/kg IV). Comparisons were made between the effects of baclofen and the effects of baclofen in the presence of CGP (B) CGP36742 significantly reversed the effects of baclofen (7 μmol/kg) on latency. Results are means ± SEM; n = 5–6 in each group. *P < 0.05 (baclofen vs. CGP baclofen).
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

6. Fig. 4
Duration of the effects of baclofen (IG, 2.8 μmol/kg) on motility parameters. The delay between drug administration and infusion of liquid meal varied between 30 and 300 minutes. Neither the (A) inhibition of TLESRs nor the (B) latency changed significantly between 30 and 300 minutes (ANOVA). Results are means ± SEM; n = 4 for each group.
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

7. Fig. 4
Duration of the effects of baclofen (IG, 2.8 μmol/kg) on motility parameters. The delay between drug administration and infusion of liquid meal varied between 30 and 300 minutes. Neither the (A) inhibition of TLESRs nor the (B) latency changed significantly between 30 and 300 minutes (ANOVA). Results are means ± SEM; n = 4 for each group.
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions

8. Fig. 5
Plasma profile of baclofen after IV (○) and IG (●) administration (n = 8 in each group). The drug was absorbed rapidly and completely from the gastrointestinal tract, and there was very little interindividual variation.
Gastroenterology  , DOI: ( /S (99) )
Copyright © 1999 American Gastroenterological Association Terms and Conditions