1. 30-day mean survival by treatment and nesiritide mortality HR in meta-analysis
Calculation
Nesiritide (%)
Control (%) HR
(95% CI) p
Unadjusted
93.5
96.0
1.86
( )
0.04
Adjusted —
1.80
( )
0.057
Sackner-Bernstein JD et al. JAMA 2005; 293:

2. Pooled 30-day risk of death with nesiritide at low and high doses compared with control group
Studies
HR (95% CI) p
VMAC, PROACTION, NSGET, starting dose, g/kg/min
1.86 ( )
0.04
VMAC, PROACTION, starting dose 0.01 g/kg/min
1.89 ( )
0.052
Sackner-Bernstein JD. Heart Failure Society of America 2005 Annual Scientific Meeting; September 18-21, 2005; Boca Raton, FL.