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Common Ground: Stem Cell Approaches Find Shared Pathways Underlying ALS
Soledad Matus, Danilo B. Medinas, Claudio Hetz Cell Stem Cell Volume 14, Issue 6, Pages (June 2014) DOI: /j.stem Copyright © 2014 Elsevier Inc. Terms and Conditions
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Figure 1 Discovery of Common Molecular Mechanisms of ALS Pathogenesis using iPSC-Derived Human Motoneurons Recent studies using human motoneuron cultures from ALS patients with distinct genetic mutations have identified transversal pathological mechanisms, facilitating the development of experimental strategies to revert distinct disease features, including abnormal protein and RNA aggregation, hyperexcitability, morphological alterations, and cell death. Cell Stem Cell , DOI: ( /j.stem ) Copyright © 2014 Elsevier Inc. Terms and Conditions
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