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The anion study: effect of different crystalloid solutions on acid base balance, physiology, and survival in a rodent model of acute isovolaemic haemodilution 

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Presentation on theme: "The anion study: effect of different crystalloid solutions on acid base balance, physiology, and survival in a rodent model of acute isovolaemic haemodilution "— Presentation transcript:

1 The anion study: effect of different crystalloid solutions on acid base balance, physiology, and survival in a rodent model of acute isovolaemic haemodilution  N.J. Ekbal, P. Hennis, A. Dyson, M. Mythen, M.F.M. James, M. Singer  British Journal of Anaesthesia  Volume 120, Issue 6, Pages (June 2018) DOI: /j.bja Copyright © 2018 The Author(s) Terms and Conditions

2 Fig 1 Study plan. Bv, 10% blood volume; LVIDD, left ventricular internal diameter in diastole. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 The Author(s) Terms and Conditions

3 Fig 2 Impact of chloride-, acetate-, and lactate-based fluids on (a) Kaplan–Meier plot of survival time with progressive haemodilution, (b) volume required to maintain ventricular filling (median, inter-quartile and full range), (c) haemoglobin (mean and sd), and (d) serum glucose (mean and sd). AS, acetate-based solution; CS, chloride-based solution; LS, lactate-based solution. n = 15 per group. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 The Author(s) Terms and Conditions

4 Fig 3 Impact of chloride-, acetate-, and lactate-based fluids on serum levels of (a) chloride, (b) bicarbonate, (c) lactate, (d) arterial pH, (e) strong ion difference (SID), and (f) anion gap. All data are mean and sd. *Significant differences between groups, P < 0.05. AS, acetate-based solution; CS, chloride-based solution; LS, lactate-based solution. n = 15 per group. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 The Author(s) Terms and Conditions

5 Fig 4 Impact of chloride-, acetate-, and lactate-based fluids on (a) arterial carbon dioxide tension, (b) serum potassium, and (c) serum sodium. All data are mean and sd. AS, acetate-based solution; CS, chloride-based solution; LS, lactate-based solution. n = 15 per group. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 The Author(s) Terms and Conditions

6 Fig 5 Impact of chloride-, acetate-, and lactate-based fluids on (a) stroke volume, (b) heart rate, (c) blood pressure, (d) arterial oxyhaemoglobin saturation, and (e) skeletal muscle tissue oxygen tension. All data are mean and sd. AS, acetate-based solution; LS, lactate-based solution; S, chloride-based solution; tPO2, muscle tissue oxygen tension. n = 15 per group. British Journal of Anaesthesia  , DOI: ( /j.bja ) Copyright © 2018 The Author(s) Terms and Conditions

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