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Tackling Pain at the Source: New Ideas about Nociceptors

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Presentation on theme: "Tackling Pain at the Source: New Ideas about Nociceptors"— Presentation transcript:

1 Tackling Pain at the Source: New Ideas about Nociceptors
William D Snider, Stephen B McMahon  Neuron  Volume 20, Issue 4, Pages (April 1998) DOI: /S (00)81003-X

2 Figure 1 Two Major Nociceptor Classes
The diagram shows peripheral and central target fields, trophic factor dependence, and biochemical properties of the two major classes of cutaneous nociceptors. The CGRP/TrkA population represents roughly 40% of DRG neurons in rodents, whereas the IB4 population represents roughly 30%. Both populations of nociceptors are sensitive to capsaicin; these presumably express either VR1 or another member of the VR1 family. Which is the case cannot be taken as established until appropriate colocalization studies are performed. Neuron  , DOI: ( /S (00)81003-X)


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