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Serial Backcross Mapping of Multiple Loci Associated with Resistance to Leishmania major in Mice
Amy M Beebe, Smita Mauze, Nicholas J Schork, Robert L Coffman Immunity Volume 6, Issue 5, Pages (May 1997) DOI: /S (00)80343-X
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Figure 1 Phenotyping of Mice Infected with L. major in the Footpad
Lesion progression was monitored by measurement of footpad swelling and development of open necrotic lesions, as indicated by filled symbols. Mice were categorized as resistant (circles), intermediate (triangles), or susceptible (squares). Immunity 1997 6, DOI: ( /S (00)80343-X)
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Figure 2 Pedigree of Genotyped Mice
Lineage chart beginning with 5 resistant N2 mice from which all genotyped mice were derived. Next to each mouse number, in parentheses, is the number of resistant and susceptible progeny respectively. Immunity 1997 6, DOI: ( /S (00)80343-X)
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Figure 3 Phenotyping of Chromosome 11 Congenics Infected with L. major in the Footpad Congenic mice were BALB/c background with the centromeric 40 cM of chromosome 11 homozygous for B10.D2 alleles. Comparison of male (diamonds) and female (triangles) congenics to male BALB/c (squares), and (BALB/c × B10.D2) F1 controls (circles). Immunity 1997 6, DOI: ( /S (00)80343-X)
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