1. Peptide insertions in reverse transcriptase pol gene of human immunodeficiency virus type 1 as a rare cause of persistent antiretroviral therapeutic failure 
Véronique Schneider, Jérôme Legoff, Laurent Bélec, Nathalie Delphin, Corinne Dutreuil, Ali Kara-Mostefa, Willy Rozenbaum, Jean- Claude Nicolas 
Clinical Microbiology and Infection 
Volume 10, Issue 2, Pages (February 2004)
DOI: /j x x
Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

2. Fig. 1
Schematic representation of treatment history and codons 67–71 of the RT pol gene for 11 patients whose HIV-1 variants had peptide rearrangements. Black circles depict nucleoside reverse transcriptase inhibitor; black triangles depict non-nucleoside reverse transcriptase inhibitor; black squares depict protease inhibitor. Antiretroviral drug regimens are shown in detail in Table 1. Vertical lines indicate therapeutic shift. Open circles indicate strains without insertions. Grey circles indicate insertion-containing strains. Triangles, diamonds and squares in grey indicate genetic evolution in codons 67–71. Open arrows indicate time of first diagnosis of insertion rearrangement.
Clinical Microbiology and Infection  , DOI: ( /j x x)
Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions

3. Fig. 2
Temporal evolution of circulating CD4 T-cell count (CD4 as black diamonds in cells/μL) and HIV-1 RNA viral load (VL as open circles in log copies/mL) for 11 patients whose HIV-1 variants contained peptide rearrangements in the RT pol gene. Vertical lines represent the time of the first discovery of insertion rearrangements.
Clinical Microbiology and Infection  , DOI: ( /j x x)
Copyright © 2004 European Society of Clinical Infectious Diseases Terms and Conditions