1. Pyruvate Dehydrogenase
Complex w/ 3 parts
Controlled by phosphoryllation state
RATE LIMITING enzyme for lactate production vs. CHO oxidation, and potential mediator of mitochondrial respiration
Activation of PDC and tca substrate administration substantially increases mitochondrial respiration
Inhibited by NADH and acetyl COA

2. KREBS CYCLE Functions are: CO2 production ATP production
NADH/FADH production-most important
Control
Redox potential controls all dehydrogenases
Increased ADP controls isocitrate dehydrogenase

3. Electron Transport Chain
1 NADH + H+ = 3 ATP
1 FADH2 = 2 ATP
NADH + H+
2 H+
2e-
1/2O2
ADP + P
ATP
H20
FADH2
Mitochondrial membrane
Mitochondrial respiration turned on by cytosolic NADH, TCA cycle substrate (specifically Acylcarnitine)

4. Control of ETC via Creatine Phosphate Shuttle
PCr supplementation does not help mitochondrial CK

5. Fatty Acid Mobilization
PKA = Protein Kinase A

6. Fatty Acid Activation and Translocation

7. Beta-Oxidation

8. Ketogenesis