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Therapeutic targets of the inflammasome pathway.

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1 Therapeutic targets of the inflammasome pathway.
Therapeutic targets of the inflammasome pathway. Recognition of pathogen-associated molecular patterns (PAMP) or danger-associated molecular patterns (DAMP) by inflammasome-initiating sensors leads to the activation of the inflammasome and initiation of pyroptosis and release of the bioactive form of IL1β and IL18. IL1β and IL18 engage in autocrine and paracrine signaling pathways via the IL1 receptor (IL1R) and IL18 receptor (IL18R), respectively. The inflammasome signaling pathway can be inhibited by pharmacologic inhibition of activation of the inflammasome (parthenolide, MCC950, glyburide, and BAY ), ASC oligomerization (CRID3), caspase-1 (thalidomide and belnacasan or VX-765), and IL1R (anakinra or kineret, and rilonacept or arcalyst), or neutralizing IL1β (canakinumab or ilaris) or IL18 (IL18 binding proteins or IL18BP). Rajendra Karki et al. Cancer Immunol Res 2017;5:94-99 ©2017 by American Association for Cancer Research

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