Presentation is loading. Please wait.

Presentation is loading. Please wait.

Chris A. Rogers, PhD, Alan J

Published by Modified over 6 years ago

Similar presentations

Presentation on theme: "Chris A. Rogers, PhD, Alan J"— Presentation transcript:

1 Propofol cardioplegia: A single-center, placebo-controlled, randomized controlled trial 
Chris A. Rogers, PhD, Alan J. Bryan, DM, FRCS (CTh), Rachel Nash, MSc, M. Saadeh Suleiman, PhD, DSc, Sarah Baos, PhD, Zoe Plummer, MSc, PhD, James Hillier, MA, MBBS, FRCA, Ian Davies, MB, BCh(Wales), FRCA, Dip ABA, Richard Downes, ACP, Eamonn Nicholson, ACP, Barnaby C. Reeves, DPhil, MSc, MA, Gianni D. Angelini, MD, MCh, FRCS, FETCS  The Journal of Thoracic and Cardiovascular Surgery  Volume 150, Issue 6, Pages e13 (December 2015) DOI: /j.jtcvs Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Participant flow. CABG, Coronary artery bypass grafting; AVR, aortic valve replacement; CPB, cardiopulmonary bypass; LV, left ventricular; PIL, Patient Information Leaflet. *Patients may be ineligible for >1 reason. †Safety population identical to analysis population. ‡Two participants (1 randomized to propofol, 1 to intralipid) were withdrawn before surgery, but willing to continue with trial data collection. Both were found to be ineligible after randomization. The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Cardiac troponin T response over time. Geometric mean and 95% confidence interval (CI) of cardiac troponin T level at each time point and geometric mean ratio (GMR) for the effect of propofol versus intralipid on cardiac troponin T release (95% CI). Pre-op, Preoperative; Post-op, postoperative. The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Concentrations over time. A, Lactate (all participants). B, pH Levels (all participants), C, Creatinine (coronary artery bypass grafting [CABG] participants). D, Creatinine (aortic valve replacement [AVR] participants). Geometric mean and 95% confidence interval (CI) at each study time point by group, and geometric mean ratio (GMR) and 95% CI for the effect of propofol versus intralipid on lactate (all participants), creatinine (CABG participants), and creatinine (AVR participants). Mean and standard deviation (SD) at each study time point by group, and mean difference (MD) and 95% CI for the effect of propofol versus intralipid on pH level (all participants). Pre-op, Preoperative; Post-op, postoperative. The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E1 Effect of propofol on cardiac troponin T release by diabetes status. GMR, Geometric mean ratio; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

6 Figure E2 Effect of propofol on troponin T release: sensitivity analyses. GMR, Geometric mean ratio; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

7 Figure E3 Quality of life scores at 3 months. EQ-5D, EQ-5D health questionnaire; VAS, visual analog scale; CROQ, Coronary Revascularisation Outcome Questionnaire; CABG, coronary artery bypass graft; MLHFQ, Minnesota Living with Heart Failure Questionnaire; MD, mean difference; OR, odds ratio; AVR, aortic valve replacement; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

8 Figure E4 Effect of propofol on quality-of-life scores: sensitivity analyses. EQ-5D, EQ-5D health questionnaire; VAS, visual analog scale; CROQ, Coronary Revascularisation Outcome Questionnaire; CABG, coronary artery bypass graft; MLHFQ, Minnesota Living with Heart Failure Questionnaire; MD, mean difference; OR, odds ratio; AVR, aortic valve replacement; CI, confidence interval. The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

9 Cardiac troponin T level over time, expressed as geometric mean ratio (GMR) (95% confidence interval) for propofol versus intralipid (placebo). The Journal of Thoracic and Cardiovascular Surgery  , e13DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Download ppt "Chris A. Rogers, PhD, Alan J"

Similar presentations

Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary.

Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary.
Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction 

Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction 
Chris A. Rogers, PhD, Alan J

Chris A. Rogers, PhD, Alan J
The “occasional open heart surgeon” revisited

The “occasional open heart surgeon” revisited
Manuel J. Antunes, MD, PhD, DSc 

Manuel J. Antunes, MD, PhD, DSc 
Benefits and risks of using clopidogrel before coronary artery bypass surgery: Systematic review and meta-analysis of randomized trials and observational.

Benefits and risks of using clopidogrel before coronary artery bypass surgery: Systematic review and meta-analysis of randomized trials and observational.
Factors associated with postoperative atrial fibrillation and other adverse events after cardiac surgery  Emmanuel Akintoye, MD, MPH, Frank Sellke, MD,

Factors associated with postoperative atrial fibrillation and other adverse events after cardiac surgery  Emmanuel Akintoye, MD, MPH, Frank Sellke, MD,
Aortic valve replacement in low-flow, low-gradient aortic stenosis: Left ventricular ejection fraction matters  Victor Dayan, MD, PhD, Philippe Pibarot,

Aortic valve replacement in low-flow, low-gradient aortic stenosis: Left ventricular ejection fraction matters  Victor Dayan, MD, PhD, Philippe Pibarot,
Ventilator-associated pneumonia after cardiac surgery: A meta-analysis and systematic review  Siyi He, MD, Bocheng Chen, MD, Wei Li, MD, Junyan Yan, MD,

Ventilator-associated pneumonia after cardiac surgery: A meta-analysis and systematic review  Siyi He, MD, Bocheng Chen, MD, Wei Li, MD, Junyan Yan, MD,
Rapid deployment or sutureless versus conventional bioprosthetic aortic valve replacement: A meta-analysis  Suk Ho Sohn, MD, Myoung-jin Jang, PhD, Ho.

Rapid deployment or sutureless versus conventional bioprosthetic aortic valve replacement: A meta-analysis  Suk Ho Sohn, MD, Myoung-jin Jang, PhD, Ho.
Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients.

Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients.
Percutaneous coronary invervention versus coronary artery bypass grafting: A meta- analysis  Yolba Smit, MD, MSc, Joan Vlayen, MD, Hetty Koppenaal, MD,

Percutaneous coronary invervention versus coronary artery bypass grafting: A meta- analysis  Yolba Smit, MD, MSc, Joan Vlayen, MD, Hetty Koppenaal, MD,
Equivalent outcomes after coronary artery bypass graft surgery performed by consultant versus trainee surgeons: A systematic review and meta-analysis 

Equivalent outcomes after coronary artery bypass graft surgery performed by consultant versus trainee surgeons: A systematic review and meta-analysis 
Pre-existing psychological depression confers increased risk of adverse cardiovascular outcomes following cardiac surgery: A systematic review and meta-analysis 

Pre-existing psychological depression confers increased risk of adverse cardiovascular outcomes following cardiac surgery: A systematic review and meta-analysis 
Proteinuria predicts postcardiotomy acute kidney injury in patients with preserved glomerular filtration rate  Szu-Yuan Li, MD, Chiao-Lin Chuang, MD,

Proteinuria predicts postcardiotomy acute kidney injury in patients with preserved glomerular filtration rate  Szu-Yuan Li, MD, Chiao-Lin Chuang, MD,
Systematic review and meta-analysis of randomized controlled trials assessing safety and efficacy of posterior pericardial drainage in patients undergoing.

Systematic review and meta-analysis of randomized controlled trials assessing safety and efficacy of posterior pericardial drainage in patients undergoing.
Off-pump coronary artery bypass grafting does not preserve renal function better than on-pump coronary artery bypass grafting: Results of a case-matched.

Off-pump coronary artery bypass grafting does not preserve renal function better than on-pump coronary artery bypass grafting: Results of a case-matched.
Ventilator-associated pneumonia after cardiac surgery: A meta-analysis and systematic review  Siyi He, MD, Bocheng Chen, MD, Wei Li, MD, Junyan Yan, MD,

Ventilator-associated pneumonia after cardiac surgery: A meta-analysis and systematic review  Siyi He, MD, Bocheng Chen, MD, Wei Li, MD, Junyan Yan, MD,
The American Association for Thoracic Surgery 2016 Ethics Forum: Cost-effectiveness and the ethics of left ventricular assist device therapy  John W.C.

The American Association for Thoracic Surgery 2016 Ethics Forum: Cost-effectiveness and the ethics of left ventricular assist device therapy  John W.C.
Niv Ad, MD, Rakesh M. Suri, MD, DPhil, James S

Niv Ad, MD, Rakesh M. Suri, MD, DPhil, James S

Similar presentations

Ads by Google