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The Effects of Interleukin 10 and Interferon γ Cytokine Gene Polymorphisms on Survival after Autologous Bone Marrow Transplantation for Patients with.

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Presentation on theme: "The Effects of Interleukin 10 and Interferon γ Cytokine Gene Polymorphisms on Survival after Autologous Bone Marrow Transplantation for Patients with."— Presentation transcript:

1 The Effects of Interleukin 10 and Interferon γ Cytokine Gene Polymorphisms on Survival after Autologous Bone Marrow Transplantation for Patients with Breast Cancer  Julie M. Wu, Debra Bensen-Kennedy, Yuji Miura, Christopher J. Thoburn, Deborah Armstrong, Georgia B. Vogelsang, Allan D. Hess  Biology of Blood and Marrow Transplantation  Volume 11, Issue 6, Pages (June 2005) DOI: /j.bbmt Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Overall survival of patients with metastatic breast cancer treated with autologous BMT and autologous GVHD induction. Of the 86 patients evaluated, 40 (46%) had stage I or II disease, 15 (17%) had stage III disease, and 31 (36%) had stage IV disease. AUTO indicates autologous. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Overall survival in patients with clinical autologous GVHD and in patients who did not develop any clinical evidence of autoaggression. Of the 87 patients evaluated, 29 developed clinical autologous GVHD, and 58 did not develop any evidence of clinical autoaggression. AUTO indicates autologous. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Overall survival and inheritance of the IL promoter alleles. Kaplan-Meier survival estimates demonstrate survival by inheritance of the IL promoter alleles. A, All patients. B, Patients with clinical autologous GVHD. C, Patients who did not develop evidence of clinical autoaggression. AUTO indicates autologous. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Overall survival and inheritance of the CA intron repeats within the IFN-γ gene. Kaplan-Meier survival estimates demonstrate survival by inheritance of the CA intron repeats within the IFN-γ gene. A, All patients. B, Patients with clinical autologous GVHD. C, Patients who did not develop evidence of clinical autoaggression. AUTO indicates autologous. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

6 Figure 5 IL-10 production and inheritance of IL Peripheral blood mononuclear cells were harvested from autologous BMT recipients and assessed ex vivo (between days 19 and 25 after BMT) for IL-10 mRNA expression by quantitative PCR. Patients were stratified according to whether they developed clinical autologous GVHD. Data expressed as relative transcripts × 10−4 standardized against the glyceraldehyde phosphate dehydrogenase (GAPDH) housekeeping gene. The median is indicated for each group (——). AUTO indicates autologous. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2005 American Society for Blood and Marrow Transplantation Terms and Conditions

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