1. Volume 18, Issue 2, Pages 151-157 (April 2011)
Long-term normalization of blood pressure in SHR and 1-kidney 1-clip rats by synthetic precursor of stable PAF analogue without systemic effects in normotensive rats 
Sergei I. Malekin, Sergei V. Kotelevtsev, Svetlana A. Gavrilova, Olga E. Fadyukova, Anna V. Golubeva, Marina I. Grinchenko, Vladimir B. Koshelev, Yuri V. Kotelevtsev, Pavel Hamet, Sergei N. Orlov 
Pathophysiology 
Volume 18, Issue 2, Pages (April 2011)
DOI: /j.pathophys
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2. Fig. 1 Chemical structure of PAF and HAG.
Pathophysiology  , DOI: ( /j.pathophys )
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3. Fig. 2
Time-dependence of the action of intravenous HAG administration (1mg/kg) on mean arterial pressure (MAP, A) and heart rate (HR, B) in SHR. During the first 60min, MAP and HR were measured at each 5-min interval and then at 24h of HAG administration. HAG or vehicle (liposomal suspension) was injected at time point zero. Means±SE obtained for 8 control and 9 HAG-treated rats are shown at time intervals corresponding to the end of each measurement.
Pathophysiology  , DOI: ( /j.pathophys )
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4. Fig. 3
Time-dependent changes of MAP (ΔMAP, A) and heart rate (ΔHR, B) in 1K1C rats subjected to intravenous administration of HAG (1mg/kg). Three rats with initial MAP of 150–205mmHg were selected for this experiment. MAP and HR were measured for 90min after drug delivery at 5-min intervals. Means±SE are shown.
Pathophysiology  , DOI: ( /j.pathophys )
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5. Fig. 4
Correlation between baseline MAP and its decline caused by HAG (ΔMAP) in 1K1C rats. MAP was measured before and within 90min of intravenous 1mg/kg HAG injection.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

6. Fig. 5
Effect of 2-week per os feeding with HAG on SBP in 1K1C rats. Rats with SBP>140mmHg were selected for this study. HAG (5mg/kg) or vehicle (olive oil) was administered chronically per os every 48h for 2 weeks. SBP was measured within 8h after each injection. Means±SE are shown.
Pathophysiology  , DOI: ( /j.pathophys )
Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions