1. Representative histopathology images from the knee joints and ankle of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA.
Representative histopathology images from the knee joints and ankle of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA. The top two panels from left to right (A and B) show staining with T blue (blue color) from the knee joints of CAIA mice treated with GalNAc–luciferase–siRNA (left panel) or with GalNAc–MASP-3–siRNA duplex 2 (right panel). The second set of two panels from left to right (C and D) show staining with T blue from the ankle joints of CAIA mice treated with GalNAc–luciferase–siRNA (left panel) or with GalNAc–MASP-3–siRNA duplex 2 (right panel). Areas of synovium (S, arrow), cartilage (C, arrow), bone marrow (BM, arrow), adipose tissue (AD, arrow), synovial cavity (SCAV, arrow), calcaneus (CA, arrow), talus (T, arrow), and meniscus (M, arrow) are identified. The sections were photographed at original magnification ×20. Scale bars shown in red in the bottom right of each panel for knee joint (A and B), 0.05 mm (50 μm, original magnification ×20), and for ankle (C and D), 0.1 mm (100 μm, original magnification ×10).
Nirmal K. Banda et al. ImmunoHorizons 2018;2:
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