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Volume 79, Issue 6, Pages 655-662 (March 2011)
De novo development of circulating anti-endothelial cell antibodies rather than pre- existing antibodies is associated with post-transplant allograft rejection Qiquan Sun, Zhen Cheng, Dongrui Cheng, Jinsong Chen, Shuming Ji, Jiqiu Wen, Chunxia Zheng, Zhihong Liu Kidney International Volume 79, Issue 6, Pages (March 2011) DOI: /ki Copyright © 2011 International Society of Nephrology Terms and Conditions
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Figure 1 Group assignment.
Kidney International , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions
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Figure 2 Impact of pre-existing anti-endothelial antibodies (AECAs) on recipient and graft survival. (a) Patient survival of AECA− group compared with AECA+ group (P=0.185 by log-rank test). (b) Renal graft survival of AECA− group compared with AECA+ group (P=0.323 by log-rank test). Kidney International , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions
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Figure 3 Impact of de novo anti-endothelial antibodies (AECAs) on outcome of renal transplantation. (a) Patient survival of AECA pre−/post+ group compared with AECA pre−/post− group (P=0.034 by log-rank test); (b) renal graft survival of AECA pre−/post+ group compared with AECA pre−/post− group (P=0.044 by log-rank test); (c) acute rejection-free survival of AECA pre−/post+ group compared with AECA pre−/post− group (P=0.044 by log-rank test); (d) graft dysfunction (serum creatinine >1.24mg/dl)-free survival of AECA pre−/post+ group compared with AECA pre−/post− group (P=0.042 by log-rank test). Kidney International , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions
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Figure 4 Positive and negative results of anti-endothelial cell antibodies (AECAs) detection by indirect immunofluorescence testing. (a) Positive staining of AECA showed a granular fluorescence in the cytoplasm of the human umbilical veins endothelial cell (HUVEC) culture, whereas nucleus was unstained. (b) Negative staining of AECA. (Original magnification, × 400.) Kidney International , DOI: ( /ki ) Copyright © 2011 International Society of Nephrology Terms and Conditions
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