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Malignant response to ajmaline challenge in SCN5A mutation carriers: Experience from a large familial study  E. Gandjbakhch, V. Fressart, G. Duthoit,

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Presentation on theme: "Malignant response to ajmaline challenge in SCN5A mutation carriers: Experience from a large familial study  E. Gandjbakhch, V. Fressart, G. Duthoit,"— Presentation transcript:

1 Malignant response to ajmaline challenge in SCN5A mutation carriers: Experience from a large familial study  E. Gandjbakhch, V. Fressart, G. Duthoit, C. Marquié, J.C. Deharo, F. Pousset, J.L. Hebert, F. Simon, C. Himbert, D. Klug, P. Charron, F. Hidden-Lucet  International Journal of Cardiology  Volume 172, Issue 1, Pages (March 2014) DOI: /j.ijcard Copyright © 2014 The Authors Terms and Conditions

2 Fig. 1 ECG tracings of ajmaline challenge from individuals III:1, II:1 and II:4. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2014 The Authors Terms and Conditions

3 Fig. 2 Family tree and clinical characteristics of SCN5A mutation-carriers. Top: family tree. Circle: female; square: male; +: presence of the p.W781X SCN5A mutation. −: absence of the mutation. Bottom: clinical characteristics of SCN5A mutation-carriers. AVB: atrio-ventricular block, RBBB: right-bundle-branch block; iRBBB: incomplete RBBB; VT: ventricular tachycardia; VF: ventricular fibrillation; SND: sinus-node-dysfunction; SA-ECG: signal-averaged ECG; ICD: implantable cardiac defibrillator; PM: pace-maker; NA: non-available data. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2014 The Authors Terms and Conditions

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