1. Volume 129, Issue 6, Pages 2064-2075 (December 2005)
Liver Gene Expression Signature of Mild Fibrosis in Patients With Chronic Hepatitis C 
Tarik Asselah, Ivan Bièche, Ingrid Laurendeau, Valérie Paradis, Dominique Vidaud, Claude Degott, Michelle Martinot, Pierre Bedossa, Dominique Valla, Michel Vidaud, Patrick Marcellin 
Gastroenterology 
Volume 129, Issue 6, Pages (December 2005)
DOI: /j.gastro
Copyright © 2005 American Gastroenterological Association Terms and Conditions

2. Figure 1 List of the 240 genes studied.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions

3. Figure 2
A hierarchic clustering analysis using GeneANOVA software23 and UPGMA was applied to group genes and samples on the basis of their similarities in gene expression levels. A signature was made based on the expression of 11 genes (shown as a dendogram). Specifically, 15 of 18 F1 (83%) and 19 of 21 F2 (90%) were classified correctly.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions

4. Figure 3
mRNA levels of 3 discriminatory genes, namely, COL1A1 (AUC ROC, .860), SCG10 (AUC ROC, .841), and IL8 (AUC ROC, .765) in the 18 F1 samples, 21 F2 samples, 17 F3 samples, and 6 F4 samples. Median values (ranges) are indicated for each subgroup.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions

5. Figure 4
(A and B) Immunostaining of CK19. (A) Patient with mild fibrosis (F1 Metavir score), few biliary ducts are labeled in the portal tract. (B) Patient with septal fibrosis (F2 Metavir score), numerous bile ducts are stained (arrow). (Antibody CK19: Dako SA; dilution 1:500). (C and D) Immunostaining of IL8. (C) Patient with mild fibrosis (F1 Metavir score), no positive cells are labeled. (D) Patient with septal fibrosis (F2 Metavir score), inflammatory cells are labeled (arrow). (Antibody IL8: Tebu-bio SA; dilution 1:20). IL8-positive cells corresponded to inflammatory cells arranged in small foci inside lobules.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2005 American Gastroenterological Association Terms and Conditions