1. Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review 
Thomas I. Siebert, M.D., Thinus F. Kruger, M.D., Daniel W. Steyn, M.D., Saleema Nosarka, M.D. 
Fertility and Sterility 
Volume 86, Issue 5, Pages (November 2006)
DOI: /j.fertnstert
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

2. FIGURE 1
Group 1: Four trials where the addition of metformin was randomized in a prospective double-blind placebo-controlled fashion in the CC-resistant patient.
Siebert. Metformin in clomiphene-resistant PCOS. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

3. FIGURE 2
Group 2: Two trials where the addition of metformin was prospectively randomized in the CC-resistant patient.
Siebert. Metformin in clomiphene-resistant PCOS. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

4. FIGURE 3 Pooled data of groups 1 and 2.
Siebert. Metformin in clomiphene-resistant PCOS. Fertil Steril 2006.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions