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Figure 2 Emerging hallmarks of T cells in rheumatoid arthritis

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1 Figure 2 Emerging hallmarks of T cells in rheumatoid arthritis
Figure 2 | Emerging hallmarks of T cells in rheumatoid arthritis. Hallmarks of T cells in rheumatoid arthritis (RA) are the ability to massively proliferate and to differentiate into proinflammatory effector cells. Several changes in the basic biologic pathways listed here distinguish T cells in patients with RA from those in healthy individuals and enable such T cells to deviate from a protective role to an autoinflammatory one. The molecular defects underlying pathogenic T cell behaviour are currently being discovered; among them is the reprogramming of cellular metabolism, which fuels the functional capabilities of arthritogenic T cells. Weyand, C. M. & Goronzy, J. J. (2017) Immunometabolism in early and late stages of rheumatoid arthritis Nat. Rev. Rheumatol. doi: /nrrheum

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Figure 1 Lymphocytes during the disease
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Figure 3 Metabolism in homeostatic chondrocytes
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Nat. Rev. Rheumatol. doi: /nrrheum

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Figure 4 Simplified T cell and antigen presenting
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