1. Regional sodium handling, urine diuretic levels, and plasma aldosterone in groups with high or low loop diuretic–induced increase in FELi or FENa. Group A had a robust natriuretic response at the proximal tubule, but the majority of sodium was reabsorbed in...
Regional sodium handling, urine diuretic levels, and plasma aldosterone in groups with high or low loop diuretic–induced increase in FELi or FENa. Group A had a robust natriuretic response at the proximal tubule, but the majority of sodium was reabsorbed in the distal nephron leading to limited natriuresis. Group B had a poor response at the proximal tubule and thus ultimately a poor natriuretic response. Group C had a robust proximal tubular response, a large but proportionately smaller distal tubular compensation than group A, and thus a good natriuretic response. Group D had a modest proximal response, but due to very little distal reabsorption, this group had a good natriuretic response. Notably, group D had significantly lower plasma aldosterone levels then the remainder of the cohort (P=0.001). Values for ↑ or ↓ represent above or below the median value. FELi was used to estimate the amount of sodium exiting the proximal tubule, FENa the amount of sodium excreted in the urine, and the difference in the two parameters the sodium reabsorbed in the distal tubule.
Veena S. Rao et al. JASN 2017;28:
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