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Management of patients receiving long-term treatment with mifepristone

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Presentation on theme: "Management of patients receiving long-term treatment with mifepristone"— Presentation transcript:

1 Management of patients receiving long-term treatment with mifepristone
Irving M. Spitz, M.D., D.Sc., Steven M. Grunberg, M.D., Nathalie Chabbert-Buffet, M.D., Tzina Lindenberg, M.Sc., Hadassa Gelber, B.Sc., Regine Sitruk-Ware, M.D.  Fertility and Sterility  Volume 84, Issue 6, Pages (December 2005) DOI: /j.fertnstert Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

2 FIGURE 1 Length of mifepristone treatment in 25 patients. Yellow bars, postmenopausal women (n = 11); blue bars, premenopausal women (n = 5); red bars, men (n = 9). Spitz. Long-term mifepristone treatment. Fertil Steril 2005. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

3 FIGURE 2 Mean (±SEM) serum blood urea nitrogen (BUN), creatinine, bilirubin and chloride (Cl) in patients with meningioma on chronic mifepristone treatment. The graphic representation includes every time point for each patient for whom data were available. However, the statistical evaluation is based on a repeated measures analysis that was performed only for the first 24 months after commencing treatment in 18 patients and for 92 months in 9 patients. The repeated-measures analysis was only applied to the patients who had full measurements over these time periods. The Huynh-Feldt test showed significant increases in bilirubin (P<.01), BUN (P<.05), and creatinine (P<.05) during the first 24 months and showed increases in bilirubin (P<.05) and decreases in chloride (P<.01) in the first 92 months. *Normal ranges. Spitz. Long-term mifepristone treatment. Fertil Steril 2005. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions


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