Presentation is loading. Please wait.

Presentation is loading. Please wait.

Xiao-Hong Lu, X. William Yang  Neuron 

Published byKrsto Tušek Modified over 6 years ago

Similar presentations

Presentation on theme: "Xiao-Hong Lu, X. William Yang  Neuron "— Presentation transcript:

1 “Huntingtin Holiday”: Progress toward an Antisense Therapy for Huntington's Disease 
Xiao-Hong Lu, X. William Yang  Neuron  Volume 74, Issue 6, Pages (June 2012) DOI: /j.neuron Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Transient ASO-Mediated Htt Lowering Produces Sustained Therapeutic Effect in HD Mice (A) A schematic to show ASOs with phosphorothioate (PS) and 2′-O-methoxyethyl (MOE) modifications that can target Htt RNA to form RNA/DNA duplex and activate RNase H-mediated degradation of Htt mRNA. (B) A schematic to illustrate the “Huntingtin Holiday” effect, a transient lowering of mHtt by ASOs in HD mice results in sustained therapeutic benefit beyond the period of disease protein suppression. Neuron  , DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

Download ppt "Xiao-Hong Lu, X. William Yang  Neuron "

Similar presentations

Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel.

Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala Marina A. Belova, Joseph J. Paton, Sara E. Morrison, C. Daniel.
The Will to Persevere Induced by Electrical Stimulation of the Human Cingulate Gyrus Josef Parvizi, Vinitha Rangarajan, William R. Shirer, Nikita Desai,

The Will to Persevere Induced by Electrical Stimulation of the Human Cingulate Gyrus Josef Parvizi, Vinitha Rangarajan, William R. Shirer, Nikita Desai,
The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages 733-745 (September 2009) DOI:

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:
Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.
Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.
The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages 844-866 (November 2013) DOI: 10.1016/j.neuron.2013.10.008 Copyright.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.
Intensity-Dependent Adaptation of Cortical and Thalamic Neurons Is Controlled by Brainstem Circuits of the Sensory Pathway Elad Ganmor, Yonatan Katz, Ilan.

Intensity-Dependent Adaptation of Cortical and Thalamic Neurons Is Controlled by Brainstem Circuits of the Sensory Pathway Elad Ganmor, Yonatan Katz, Ilan.
Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release Peng Zhou, Taulant Bacaj, Xiaofei Yang,

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release Peng Zhou, Taulant Bacaj, Xiaofei Yang,
Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages 791-806 (October 2013) DOI: 10.1016/j.neuron.2013.10.047.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron
Canonical Microcircuits for Predictive Coding Andre M. Bastos, W. Martin Usrey, Rick A. Adams, George R. Mangun, Pascal Fries, Karl J. Friston Neuron Volume.

Canonical Microcircuits for Predictive Coding Andre M. Bastos, W. Martin Usrey, Rick A. Adams, George R. Mangun, Pascal Fries, Karl J. Friston Neuron Volume.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages 38-52 (April 2008) DOI: 10.1016/j.cell.2008.03.011.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell
Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages 951-962 (June 2006) DOI: 10.1016/j.neuron.2006.04.035.

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron
Auditory Hair Cell-Afferent Fiber Synapses Are Specialized to Operate at Their Best Frequencies M.E. Schnee, D.M. Lawton, D.N. Furness, T.A. Benke, A.J.

Auditory Hair Cell-Afferent Fiber Synapses Are Specialized to Operate at Their Best Frequencies M.E. Schnee, D.M. Lawton, D.N. Furness, T.A. Benke, A.J.
Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages 1262-1272 (September 2014)

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)
Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity Avishek.

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity Avishek.
Normal Movement Selectivity in Autism Ilan Dinstein, Cibu Thomas, Kate Humphreys, Nancy Minshew, Marlene Behrmann, David J. Heeger Neuron Volume 66, Issue.

Normal Movement Selectivity in Autism Ilan Dinstein, Cibu Thomas, Kate Humphreys, Nancy Minshew, Marlene Behrmann, David J. Heeger Neuron Volume 66, Issue.
Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.
Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim, Richard.
Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes John H. Lee, Luis Tecedor, Yong Hong Chen, Alex Mas Monteys,

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes John H. Lee, Luis Tecedor, Yong Hong Chen, Alex Mas Monteys,
Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons Mitsuko Watabe-Uchida, Lisa Zhu, Sachie K. Ogawa, Archana Vamanrao, Naoshige Uchida Neuron.

Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons Mitsuko Watabe-Uchida, Lisa Zhu, Sachie K. Ogawa, Archana Vamanrao, Naoshige Uchida Neuron.

Similar presentations

Ads by Google