1. A RHIM with a View: FLYing with Functional Amyloids
Sunny Shin, Sara Cherry 
Immunity 
Volume 47, Issue 4, Pages (October 2017)
DOI: /j.immuni
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
cRHIMS Drive IMD Pathway Activation through Functional Amyloid Formation
DAP-type PGN can activate IMD signaling either at the plasma membrane by binding to PGRP-LC or from the cytoplasm by binding intracellular PGRP-LE. Kleino et al. (2017) show that this leads to cRHIM-mediated nucleation, which must then incorporate the cRHIM of Imd to form a fibril. This presents the DD of Imd to the downstream signaling components including FADD, which interacts through its DD. Pirk contains a cRHIM that can interact with the cRHIMs of Imd or PGRPs and thereby block amyloid formation preventing signaling.
Immunity  , DOI: ( /j.immuni )
Copyright © 2017 Elsevier Inc. Terms and Conditions