1. Ibuprofen Transport into and through Skin from Topical Formulations: In Vitro–In Vivo Comparison 
Christophe Herkenne, Aarti Naik, Yogeshvar N. Kalia, Jonathan Hadgraft, Richard H. Guy 
Journal of Investigative Dermatology 
Volume 127, Issue 1, Pages (January 2007)
DOI: /sj.jid
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

2. Figure 1
Ibuprofen concentration profiles across SC in vivo. In vivo concentration versus normalized SC depth (x/L) profiles of ibuprofen following 30minutes treatment with Artofen, Brufen, Iprogel, and Optifen gels.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

3. Figure 2
Ibuprofen transport across a silicone membrane in vitro. Steady-state flux of ibuprofen through a silicone membrane of 120μm thickness (mean±SD, n=4).
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

4. Figure 3
Ibuprofen transport across excised porcine skin in vitro. Cumulative permeation of ibuprofen from four gels through dermatomed pig ear skin (mean±SD, n=7–9).
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

5. Figure 4
Relative fluxes of drug across silicone and porcine skin membranes in vitro. Comparison of the average (n=4–9) in vitro steady-state fluxes of ibuprofen from various formulations across silicone membrane and dermatomed pig ear skin.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

6. Figure 5
Ibuprofen fluxes across porcine (in vitro) and human (in vivo) skin. In vivo (open bars)–in vitro (hatched bars) comparison of the steady-state flux (mean±SD, n=4–9).
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

7. Figure 6
Ibuprofen diffusivity parameters through porcine (in vitro) and human (in vivo) skin. In vivo (open bars)–in vitro (hatched bars) comparison of the deduced diffusion parameter (mean±SD, n=4–9).
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

8. Figure 7
Ibuprofen partition coefficients into porcine (in vitro) and human (in vivo) skin. In vivo (open bars)–in vitro (hatched bars) comparison of the deduced K values (mean±SD, n=4–9).
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

9. Figure 8
Device for determination of silicone membrane – gel partition coefficients. Determination of the silicone–gel partition coefficient. Membranes were equilibrated with each gel (n=3) for 48hours.
Journal of Investigative Dermatology  , DOI: ( /sj.jid )
Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions