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Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders  Liang Qiang, Ryousuke Fujita, Asa Abeliovich  Neuron 

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Presentation on theme: "Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders  Liang Qiang, Ryousuke Fujita, Asa Abeliovich  Neuron "— Presentation transcript:

1 Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders  Liang Qiang, Ryousuke Fujita, Asa Abeliovich  Neuron  Volume 78, Issue 6, Pages (June 2013) DOI: /j.neuron Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Schematic of Reprogramming-Based Approaches for the Generation of Human Neuron Models of Disease These approaches include the generation of iPSC that are then differentiated to mature neurons, directed conversion to induced neurons or directed conversion to dividing neural progenitors, that can give rise to mature CNS cell types. Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

3 Figure 2 Therapeutic Strategies and Somatic Cell Reprogramming Technologies “Personalized medicine” approaches include the generation of autologous “replacement” cells, as well as the identification of therapeutics that are particularly effective for a given individual. Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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