1. Under Pressure: When a Transformed Environment Pushes Cells to Malignancy 
María García-Fernández, Simón Méndez-Ferrer 
Cell Stem Cell 
Volume 19, Issue 5, Pages (November 2016)
DOI: /j.stem
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1 Mechanism of Leukemia Predisposition by Sbds Loss in MSPCs
This diagram shows the mechanism proposed by Zambetti et al. to illustrate the contribution of Sbds mutation in mesenchymal stem/progenitor cells (MSPCs) to reduced bone formation and impaired hematopoiesis (myelodysplasia) in Shwachman-Diamond Syndrome. The loss of Sbds in osterix+ MSPCs (right panel) impairs osteoblastic differentiation and induces p53. S100A8/A9 secreted by MSPCs activates TLR4 in hematopoietic stem/progenitor cells (HSPCs) and causes mitochondrial hyperpolarization and an increase of ROS and DNA damage response. As a consequence, leukemic-prone HSPCs accumulate.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2016 Elsevier Inc. Terms and Conditions