1. Cyclin dependent kinase inhibitor 1 C is a female-specific marker of left ventricular function after acute myocardial infarction 
Torkia Lalem, Lu Zhang, Markus Scholz, Ralph Burkhardt, Victoria Saccheti, Andrej Teren, Joachim Thiery, Yvan Devaux 
International Journal of Cardiology 
Volume 274, Pages (January 2019)
DOI: /j.ijcard
Copyright © 2018 Elsevier B.V. Terms and Conditions

2. Fig. 1
Expression of CDKN1C in AMI patients. CDKN1C was measured by quantitative PCR in blood samples recovered at reperfusion in 447 AMI patients. (A) Boxplots show the expression of CDKN1C in all patients according to their 4-month EF. Patients with EF ≥ 50% were considered as having a pEF, 40% ≤ EF < 49% was considered as mrEF, and EF < 40% was considered as rEF. (B) Expression levels of CDKN1C in men and women. (C) Expression levels of CDKN1C in the three EF groups separately in men and women. mrEF: mid-range ejection fraction; pEF: preserved ejection fraction; rEF: reduced ejection fraction.
International Journal of Cardiology  , DOI: ( /j.ijcard )
Copyright © 2018 Elsevier B.V. Terms and Conditions

3. Fig. 2
Multivariable analyses. Ordinal regression was used to evaluate the association of CDKN1C and the demographic and clinical parameters of patients with LV dysfunction at 4 months, in all patients (A), and in men (B) and women separately (C). Odds ratios (OR) with 95% confidence intervals (CI) are shown. X axis is in log scale. BMI: body mass index; CI: confidence intervals; CPK: creatine phosphokinase; MI: myocardial infarction; Nt-proBNP: N-terminal pro-brain natriuretic peptide; OR: adds ratios.
International Journal of Cardiology  , DOI: ( /j.ijcard )
Copyright © 2018 Elsevier B.V. Terms and Conditions

4. Supplementary Fig. 1
Univariate analyses. The association between demographic and clinical parameters of patients, and expression levels of CDKN1C, with LV dysfunction at 4 months was assessed with univariate ordinal regression in all patients (A), and in men (B) and women (C) separately. Odds ratios (OR) with 95% confidence intervals (CI) are shown. X axis is in log scale. BMI: body mass index; CI: confidence intervals; CPK: creatine phosphokinase; MI: myocardial infarction; Nt-proBNP: N-terminal pro-brain natriuretic peptide; OR: adds ratios.
International Journal of Cardiology  , DOI: ( /j.ijcard )
Copyright © 2018 Elsevier B.V. Terms and Conditions

5. Supplementary Fig. 2
Bootstrap internal validation showing the percentage of times, over 150 bootstrap samples, that a cardiac biomarker or CDKN1C has been selected as providing the best improvement of the prediction of the clinical model, based on decreased Akaike information criterion (AIC). The variables included in the clinical model were age, BMI, previous MI, diabetes, hypertension, hypercholesterolemia, smoking, MI type (STEMI vs NSTEMI), ischemic time, and leucocytes. The bootstrap was conducted in all patients (A), and in men (B) and women (C) separately. CPK: creatine phosphokinase; cTnT: cardiac Troponin T; Nt-proBNP: N-terminal pro-brain natriuretic peptide.
International Journal of Cardiology  , DOI: ( /j.ijcard )
Copyright © 2018 Elsevier B.V. Terms and Conditions