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Compound polyglactin 910/polypropylene small vessel prostheses

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Presentation on theme: "Compound polyglactin 910/polypropylene small vessel prostheses"— Presentation transcript:

1 Compound polyglactin 910/polypropylene small vessel prostheses
Howard P. Greisler, M.D., Dae Un Kim, M.D., James W. Dennis, M.D., John J. Klosak, M.D., Katherine A. Widerborg, M.D., Eric D. Endean, M.D., Richard M. Raymond, Ph.D., Joan Ellinger  Journal of Vascular Surgery  Volume 5, Issue 4, Pages (April 1987) DOI: / (87) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

2 Fig. 1 Gross photograph of the luminal surface of a longitudinally opened polyglactin 910/polypropylene prosthesis-tissue complex explanted after 1 year. The residual polypropylene weave is seen through this translucent inner capsule. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

3 Fig. 2 Thickness of inner capsule tissues 1 month after implantation of woven 69% PG910/31% polypropylene prostheses. Significant differences are found when compared with previously reported inner capsule thickness 1 month after implantation of woven 100% PG910 or woven 70% PG910/30% Dacron prostheses.5 Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

4 Fig. 3 A, Midportion of specimen at 1 month shows portion of outer capsule with PG910 inclusions (small arrows) within macrophages and giant cell cytoplasm. The larger polypropylene filaments (large arrows) are surrounded but not phagocytized by macrophages and giant cells (hematoxylin-eosin stain; original magnification × 550). B, Transmission electron micrograph of giant cell with portions of two nuclei (arrows) and large PG910 intracytoplasmic inclusion. Cytoplasmic processes are seen infiltrating into the substance of the PG910 (original magnification × 6800). Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

5 Fig. 4 Midportion of specimen at 1 month shows inner and outer capsules and prosthetic material (P). Capillaries (arrows) appear both in the outer capsule and area of the prosthetic interstices. Inner capsule tissues are primarily myofibroblasts and collagen beneath a confluent cellular luminal surface (hematoxylin-eosin stain; original magnification × 135). Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

6 Fig. 5 A, Midportion of specimen at 6 months shows smooth, confluent endothelial-like luminal surface lining on inner capsule of smooth muscle-like myofibroblasts and collagen (hematoxylin-eosin stain; original magnification × 550). B, Scanning electron micrograph of midportion of specimen at 2 months shows confluent endothelial-like luminal surface (original magnification × 1560). Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

7 Fig. 6 Midportion of specimen at 12 months shows capillary (arrows) infiltration of outer capsule, prosthetic interstices, and inner capsule tissues (hematoxylin-eosin stain; original magnification × 345). Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

8 Fig. 7 Midportion of specimen at 12 months shows calcium deposition and ossification (arrows) of deeper portion of inner capsule in the area of the polypropylene material despite presence of cellular luminal surface (hematoxylin-eosin stain; original magnification × 345). Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

9 Fig. 8A Transmission electron micrograph of poorly differentiated myofibroblasts in the inner capsule of 1-month specimens. Small amounts of rough endoplasmic reticulum (R) and scanty myofilaments (arrows) with dense bodies are seen. Surrounding the cells is abundant collagen (C) in the extracellular matrix. (original magnification × 1100). Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

10 Fig. 8B and 8C. B, Transmission electron micrograph of myofibroblast in inner capsule of a 2-month specimen. Both fibroblast-like (R) and smooth muscle cell-like (arrows) characteristics are more developed than in Fig. 8A. C, Transmission electron micrograph of smooth muscle cell-like myofibroblast in inner capsule of 4-month specimen. Abundant myofilaments (arrows) with dense bodies are seen throughout the cytoplasm with a marked attenuation of rough endoplasmic reticulum (R) in the perinuclear region. Portions of three other smooth muscle cell-like myofibroblasts can be seen. (Original magnifications × 1100.) Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

11 Fig. 9 A, Scanning electron micrograph of midportion of luminal surface of a 12-month specimen shows confluent oriented endothelial-like layer. B, Scanning electron micrograph of luminal surface of normal rabbit aorta demonstrates similarity to regenerated blood-contacting surface seen in A. (Original magnifications for A and B, × 500.) Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

12 Fig. 10 Mean rates of productions of 6-keto-PGF1α per square millimeter of surface area, each expressed as a ratio of experimental segment to control aortic segment from the same animal. The 5 to 30 minute curve (solid line) represents the production rate before sodium arachidonate was added to the system, the 35 to 60 minute curves (dashed line) after its addition, and the 5 to 60 minute curve (dotted line) the total perfusion period. Journal of Vascular Surgery 1987 5, DOI: ( / (87) ) Copyright © 1987 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions


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