1. Knowledge Representation, Structuring and Ontology Development
Arden Homestead
June 4-5, 2003

2. Knowledge-Based Terminology
History
Theory
Principles
Reality
Other efforts
Additional applications
Additional research

3. History DXplain: Juvenile Polyarteritis Nodusm and Kawasaki Disease?
Comparing disease descriptions to detect redundancy
Detecting redundancy in the COSTAR Directory
UMLS
CPMC CIS Terminology

4. Theory
Knowledge-based approach should make high-quality terminologies easier to create
Knowledge-based approach should make terminologies easier to use
Knowledge-based approach should make terminologies easier to maintain

5. Principles Concept-oriented Multiple hierarchies Semantic relations
Inheritance

6. Reality – The MED Local terminologies National standards UMLS
Other projects
77,000 concepts
Lab tests and drugs have definitions

7. Reality – Use of the MED
Translating local codes for storage in repository
Display spreadsheets for summary reporting
Class-based decision support
Translation for information retrieval

11. Problem-Oriented Views of the EMR
MED
Heart
Heart
Disease
Chest
Cardiac
Enzyme
Chest X ray
Intravascular
CK Test
Creatine
Kinase
Congestive
Heart Failure
Angina
Chest X ray
2 View
Admission :2/14/98
Angina
Discharge :1/15/99
CHF
Radiology :2/23/99
Chest X Ray
Lab :1/1/99
Cardiac Enzyme Test
Lab :1/1/99
Cardiac Enzyme Test
Radiology :2/23/99
Chest X Ray
Radiology :2/28/96
Head CT
Lab :12/28/96
Sickle Cell Test
Admission :3/14/96
Stroke
Admission :2/14/98
Angina
Blood Type Test
Radiology :2/1/97
Knee X Ray
Discharge :1/15/99
CHF
Medical
Record

15. Reality – MED Maintenance
Semi-automated lab update
Automated pharmacy update
Manual updates (“ASV”)
Some audits done routinely

16. Other efforts
SNOMED
Galen
UMLS
KIF
Conceptual graphs

17. Additional applications
Infobutton Manager
Cornell neurobiology
At CPMC?

21. Towards a Columbia–Cornell Collaboration
Laboratory of Neuroinformatics
Weill-Cornell campus
Funded by the NIH’s Human Brain Project
We seek collaborators to help develop BrainML
Data description language for experimental neurobiology
XML syntax, XML Schema lexical structure
Lexicon trees codify values for neuroscience attributes
Built on our BrainMetaL metalanguage
Not a single note but a suite

22. A Sample BrainML Lexicon

23. Additional research Additional representations (Protégé)
Knowledege-based editing
Local Updates
Visualization
Richer semantics