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Epigenetic Mechanisms of Longevity and Aging

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Presentation on theme: "Epigenetic Mechanisms of Longevity and Aging"— Presentation transcript:

1 Epigenetic Mechanisms of Longevity and Aging
Payel Sen, Parisha P. Shah, Raffaella Nativio, Shelley L. Berger  Cell  Volume 166, Issue 4, Pages (August 2016) DOI: /j.cell Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 The Epigenetic Hallmarks of Senescence and Aging
(A–J) Senescence and aging are characterized by (A) loss of histones, (B) imbalance of activating and repressive modifications, (C) transcriptional changes, (D) losses and gains in heterochromatin, (E) breakdown of nuclear lamina, (F) global hypomethylation and focal hypermethylation, and (G) chromatin remodeling. These changes are heavily dictated by (H) environmental stimuli and (I) nutrient availability that in turn (J) alter intracellular metabolite concentrations. Cell  , DOI: ( /j.cell ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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