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Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A.

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Presentation on theme: "Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury  Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A."— Presentation transcript:

1 Resveratrol, a Natural Red Wine Polyphenol, Reduces Ischemia-Reperfusion–Induced Spinal Cord Injury 
Sadi Kaplan, MD, Gianluigi Bisleri, MD, Jeffrey A. Morgan, MD, Faisal H. Cheema, MD, Mehmet C. Oz, MD  The Annals of Thoracic Surgery  Volume 80, Issue 6, Pages (December 2005) DOI: /j.athoracsur Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Mean neurologic scores of animals demonstrated a significant difference (p < 0.001) between control and treatment groups at each time point (8 hours, 16 hours, and 24 hours). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Hematoxylin and eosin staining (magnification, ×100). (A) Group A, resveratrol-treated rabbits. (B) Group B, nontreated rabbits. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Total number of motor neurons in the gray matter.
The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Effect of resveratrol pretreatment on spinal cord neutrophil accumulation in rabbits 24 hours after surgery. Myeloperoxidase (MPO) activity (ΔAbs 460 nm/min) was determined to quantify neutrophil deposition in the ischemic reperfused spinal cord tissue. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Malondialdehyde (MDA) levels of lumbar spinal cord segments 24 hours after reperfusion. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2005 The Society of Thoracic Surgeons Terms and Conditions

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