1. Lipid Soluble Hormone

2. Lipid Soluble Hormone

3. Water-Soluble Hormone
Blood capillary
Water-soluble
hormone 1
Binding of hormone (first messenger) to its receptor activates G protein, which activates adenylate cyclase
Receptor
Adenylate cyclase
Second messenger
G protein 2
Activated adenylate
cyclase converts
ATP to cAMP
ATP
cAMP
Protein kinases 6
Phosphodiesterase inactivates cAMP 3
cAMP serves as a
second messenger
to activate protein
kinases
Activated
protein
kinases 4
Activated protein kinases phosphorylate
cellular proteins
Protein
ATP
ADP
Protein - P
Millions of phosphorylated
proteins cause reactions that
produce physiological responses 5
Target cell

4. Water Soluble Hormone
Activation of G-protein coupled receptor. (I) Resting state. (II) Hormone binding produces a conformational change in the receptor that causes (III) the  subunit to exchange GDP for GTP, dissociate from the /-subunit and interact with its effector molecule. The /-subunit also interacts with its effector molecule. (IV) The  subunit converts GTP to GDP, which allows it to reassociate with the /-subunit, and the hormone dissociates from the receptor, restoring the resting state. (I).

5. Water-Soluble Hormone