1. State of Clinical HIV Research in Africa
Elly T Katabira, FRCP
Department of Medicine
Makerere University Medical School
Industry and HIV Clinical Research – Focusing on women and children
Dakar, Senegal, December 3, 2008

2. Some of the research being done in Africa
HIV prevention studies
Microbiscides studies
Male circumscion and its impact on female HIV transmission
PMTCT stuudies
HIV intervention studies
Discordant couples studies
Issues on adherence
Variuos clinical trials
For adults and children

3. Who is doing the research
Indeginous researchers
But poorly funded by local institutions
Collaborative research
Through North-South institutions
Major funding agents
Industries
On a limited scale
Their support through North instuitutions

4. Major challenges Poor infrastructure Inadequate human resources
Research monitoring infrastructure
IRBs, etc.
Ethical issues
How to involve children
Issues of consent among women
Influence on policy makers

5. Some research gaps
Appropriate interventions for children as they grow up
Impact of adolescence on ART and vice versa
Why PMTCT uptake remains low
Even when it is provided free of charge
Gender issues that influence ART adherence
Both in short term and long term