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Apoptosis-targeted therapies for cancer
John C Reed Cancer Cell Volume 3, Issue 1, Pages (January 2003) DOI: /S (02)
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Figure 1 Apoptosis pathways
Some of the better defined apoptosis pathways are depicted. FLIP, Bcl-2/Bcl-XL, and IAPs suppress specific steps in the extrinsic, intrinsic, and convergence pathways, respectively. Cancer Cell 2003 3, 17-22DOI: ( /S (02) )
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Figure 2 Signal transduction and apoptosis regulation
Some protein kinases and transcription factors are well known for their ability to modulate activity or expression of apoptosis-relevant proteins. The figure shows examples for (A) NFκB, (B) Akt, and (C) p53. Cancer Cell 2003 3, 17-22DOI: ( /S (02) )
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