1. In Vino Veritas: A Tale of Two Sirt1s?
Seung-Hoi Koo, Marc Montminy 
Cell 
Volume 127, Issue 6, Pages (December 2006)
DOI: /j.cell
Copyright © 2006 Elsevier Inc. Terms and Conditions

2. Figure 1 Resveratrol Stimulates the Sirt1-PGC-1α Pathway
Resveratrol improves insulin sensitivity in mice by stimulating mitochondrial function via the Sirt1-PGC-1α pathway. Under basal conditions PGC-1α is heavily acetylated and inactivated by GCN5. Elevations in cellular NAD+ during fasting and in response to exercise trigger the Sirt1-mediated deacetylation of PGC-1α. Deacetylated PGC-1α stimulates genes for oxidative phosphorylation in part by functioning as a coactivator for nuclear respiratory factor-1 (NRF-1). Resveratrol increases Sirt1 activation under high-fat diet conditions by increasing the affinity of Sirt1 for NAD+ and for acetylated PGC-1α.
Cell  , DOI: ( /j.cell )
Copyright © 2006 Elsevier Inc. Terms and Conditions