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P Bodies and the Control of mRNA Translation and Degradation

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Presentation on theme: "P Bodies and the Control of mRNA Translation and Degradation"— Presentation transcript:

1 P Bodies and the Control of mRNA Translation and Degradation
Roy Parker, Ujwal Sheth  Molecular Cell  Volume 25, Issue 5, Pages (March 2007) DOI: /j.molcel Copyright © 2007 Elsevier Inc. Terms and Conditions

2 Figure 1 The General Pathways and Nuclease Complexes for Degradation of Eukaryotic mRNAs Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2007 Elsevier Inc. Terms and Conditions

3 Figure 2 The mRNA Cycle: A Model for the Cycling of Eukaryotic mRNAs between Different Subcellular Compartments Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2007 Elsevier Inc. Terms and Conditions

4 Figure 3 Function of mRNAs May Reflect Competition between Assembly of Translation Initiation Complexes and Translation Repression Complexes Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2007 Elsevier Inc. Terms and Conditions

5 Figure 4 mRNA-Specific Recruitment of the General Repression and Decay Complexes Examples of how mRNA-specific regulators may recruit the general repression and decay complexes to individual transcripts, thereby promoting deadenylation, translation repression, accumulation in P bodies, and decapping. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2007 Elsevier Inc. Terms and Conditions


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