1. Doubly Dangerous: Extranodal NK/T-Cell Lymphoma
Shih-Jyun Yang, MD, Chau Yee Ng, MD, Chih-Hsun Yang, MD, Pei-Hsuan Lu, MD 
The American Journal of Medicine 
Volume 130, Issue 6, Pages (June 2017)
DOI: /j.amjmed
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
The clinical manifestations of the disease were evident. (A) The patient had symmetrical violaceous swelling on both cheeks. Deep-seated induration occurred on palpation. (B) Faint violaceous patches could be seen on her neck, upper chest, and on both arms. (C) An ulcer measuring 1.3 × 1.3 cm and covered with necrotic tissue was located on the patient's left tonsil.
The American Journal of Medicine  , DOI: ( /j.amjmed )
Copyright © 2017 Elsevier Inc. Terms and Conditions

3. Figure 2
Histopathological examination of a skin biopsy specimen was essential to the diagnosis. (A) Dense, lymphocytic infiltrates were deep in the subcutis (hematoxylin and eosin, 20×). (B) Basal cell vacuolation, marked dermal edema, and diffuse hemorrhage were seen in the superficial dermis (hematoxylin and eosin, 100×). (C) Adipocytes were rimmed by medium-sized, atypical lymphoid cells (hematoxylin and eosin, 400×). (D) Epstein-Barr encoding region or EBER in situ hybridization revealed the Epstein-Barr virus in atypical lymphoid cells (400×).
The American Journal of Medicine  , DOI: ( /j.amjmed )
Copyright © 2017 Elsevier Inc. Terms and Conditions