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Wnt Signaling: It Gets More Humorous with Age
Bryan D. White, Nghi K. Nguyen, Randall T. Moon Current Biology Volume 17, Issue 21, Pages R923-R925 (November 2007) DOI: /j.cub Copyright © 2007 Elsevier Ltd Terms and Conditions
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Figure 1 Modulating the Wnt/ß-catenin pathway in aging.
(A) While the recent study by Liu et al.[3] showed that increased Wnt signaling accelerates senescence, the question remains whether a Wnt inhibitor such as Dickkopf can delay cellular aging. (B) Inhibiting the increased Wnt activity in aged serum restores the regenerative response of stem cells. Current Biology , R923-R925DOI: ( /j.cub ) Copyright © 2007 Elsevier Ltd Terms and Conditions
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