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Anti-Tau Antibodies: Hitting the Target

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1 Anti-Tau Antibodies: Hitting the Target
Todd E. Golde, Jada Lewis, Nikolaus R. McFarland  Neuron  Volume 80, Issue 2, Pages (October 2013) DOI: /j.neuron Copyright © 2013 Elsevier Inc. Terms and Conditions

2 Figure 1 Model of Tau Seeding and Effects of Immunotherapy
Exogenous pathological tau, presumably released from neurons, “seeds” formation of tau aggregates in other neurons and induces an inflammatory response (activated microglia and astrocytes), thereby propagating neuropathology. Anti-tau antibodies probably bind to exogenous pathological tau (including fibrils) and prevent both “seeding” and non-cell-autonomous neuroimmune response. The degree to which anti-tau antibodies might also get into neurons and affect spread of tau pathology is not represented here but should be considered. Neuron  , DOI: ( /j.neuron ) Copyright © 2013 Elsevier Inc. Terms and Conditions

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