Presentation is loading. Please wait.

Presentation is loading. Please wait.

Vamsidhar Velcheti, MD, David L. Rimm, MD, PhD, Kurt A

Published byHadian Irawan Modified over 5 years ago

Similar presentations

Presentation on theme: "Vamsidhar Velcheti, MD, David L. Rimm, MD, PhD, Kurt A"— Presentation transcript:

1 Sarcomatoid Lung Carcinomas Show High Levels of Programmed Death Ligand-1 (PD- L1) 
Vamsidhar Velcheti, MD, David L. Rimm, MD, PhD, Kurt A. Schalper, MD, PhD  Journal of Thoracic Oncology  Volume 8, Issue 6, Pages (June 2013) DOI: /JTO.0b013e318292be18 Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Sarcomatoid lung carcinomas show increased PD-L1 protein levels. A, Representative microphotographs showing PD-L1 and CK positivity in giant cell lung carcinoma. Left panels include hematoxylin & eosin-stained preparations at 200× (upper) and 400× magnification (lower panel). Giant cell carcinomas show characteristic lack of typical epithelial cohesiveness, a prominent mixed inflammatory infiltrate and bizarre giant tumor cells with single or multiple nuclei and focal leukocyte engulfment (emperipolesis, arrows). The right panels show fluorescence captions of PD-L1 (upper, red channel) and CK (lower, green channel) positivity of the same sample. Nuclei were stained with 4′, 6-diamidino-2-phenylindole (blue channel). B, Representative fluorescence microphotographs showing PD-L1 staining in formalin-fixed paraffin-embedded term human placenta (upper panels) and Mel624 transfectants (lower panels). PD-L1 positivity in placental samples was restricted to the trophoblastic cells (CK positive compartment;right panel) and absent in the stromal areas (vimentin positive compartment; Vim, left panel). Bar = 100 µm. In the cell lines, PD-L1 signal was evident with a perinuclear or membranous pattern only in PD-L1-transfected Mel624 cells (bottom right panel) but not in parental cells (bottom left panel). Bar = 50 µm. C, Graph showing mean ± standard error mean PD-L1 AQUA scores in conventional NSCLC (left bar) and in Sarcomatous carcinomas (right bar). AQUA scores are expressed as arbitrary units (AU). Cases were measured in the same preparations. The number of cases in each group is indicated within each bar. **p < AQUA; automated quantitative fluorescence analysis; PD-L1, programmed death ligand-1; CK, cytokeratine; NSCLC, non–small-cell lung cancer. Journal of Thoracic Oncology 2013 8, DOI: ( /JTO.0b013e318292be18) Copyright © 2013 International Association for the Study of Lung Cancer Terms and Conditions

Download ppt "Vamsidhar Velcheti, MD, David L. Rimm, MD, PhD, Kurt A"

Similar presentations

Alpha-Actinin 4 Is Associated with Cancer Cell Motility and Is a Potential Biomarker in Non–Small Cell Lung Cancer  Ming-Chuan Wang, PhD, Ying-Hua Chang,

Alpha-Actinin 4 Is Associated with Cancer Cell Motility and Is a Potential Biomarker in Non–Small Cell Lung Cancer  Ming-Chuan Wang, PhD, Ying-Hua Chang,
Clinicopathologic Characteristics of the EGFR Gene Mutation in Non–small Cell Lung Cancer  Anne S. Tsao, MD, Xi Ming Tang, MD, PhD, Bradley Sabloff, MD,

Clinicopathologic Characteristics of the EGFR Gene Mutation in Non–small Cell Lung Cancer  Anne S. Tsao, MD, Xi Ming Tang, MD, PhD, Bradley Sabloff, MD,
Naomi Fujioka, MD, Christopher A. French, MD, Michael J

Naomi Fujioka, MD, Christopher A. French, MD, Michael J
Inflammatory Myofibroblastic Tumor of the Left Main Stem Bronchus

Inflammatory Myofibroblastic Tumor of the Left Main Stem Bronchus
Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,

Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,
Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model  Yunge Zhao, MD, PhD, Jacob.

Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model  Yunge Zhao, MD, PhD, Jacob.
Volume 145, Issue 1, Pages (April 2017)

Volume 145, Issue 1, Pages (April 2017)
EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma  Maria I. Toki, MD,

EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma  Maria I. Toki, MD,
Detection of Rearrangements and Transcriptional Up-Regulation of ALK in FFPE Lung Cancer Specimens Using a Novel, Sensitive, Quantitative Reverse Transcription.

Detection of Rearrangements and Transcriptional Up-Regulation of ALK in FFPE Lung Cancer Specimens Using a Novel, Sensitive, Quantitative Reverse Transcription.
Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model  Yunge Zhao, MD, PhD, Jacob.

Treatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model  Yunge Zhao, MD, PhD, Jacob.
EGFR Status in Mesothelioma: Possible Implications for the Efficacy of Anti-EGFR and Anti-MET Therapies  Sandra Salvi, PhD, Serena Varesano, PhD, Simona.

EGFR Status in Mesothelioma: Possible Implications for the Efficacy of Anti-EGFR and Anti-MET Therapies  Sandra Salvi, PhD, Serena Varesano, PhD, Simona.
Novel Mutations on EGFR Leu792 Potentially Correlate to Acquired Resistance to Osimertinib in Advanced NSCLC  Kai Chen, MD, Fei Zhou, MD, Wenxiang Shen,

Novel Mutations on EGFR Leu792 Potentially Correlate to Acquired Resistance to Osimertinib in Advanced NSCLC  Kai Chen, MD, Fei Zhou, MD, Wenxiang Shen,
Antibody Independent Microfluidic Cell Capture of Circulating Tumor Cells for the Diagnosis of Cancer  Eric Lim, MB, ChB, MD, MSc, FRCS, Andee Tay, BSc,

Antibody Independent Microfluidic Cell Capture of Circulating Tumor Cells for the Diagnosis of Cancer  Eric Lim, MB, ChB, MD, MSc, FRCS, Andee Tay, BSc,
Prognostic Significance of PD-L1 in Patients with Non–Small Cell Lung Cancer: A Large Cohort Study of Surgically Resected Cases  Jong-Mu Sun, MD, Wei.

Prognostic Significance of PD-L1 in Patients with Non–Small Cell Lung Cancer: A Large Cohort Study of Surgically Resected Cases  Jong-Mu Sun, MD, Wei.
A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer  Shinjiro.

A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer  Shinjiro.
Comparison of 22C3 PD-L1 Expression between Surgically Resected Specimens and Paired Tissue Microarrays in Non–Small Cell Lung Cancer  Chao Li, MD, PhD,

Comparison of 22C3 PD-L1 Expression between Surgically Resected Specimens and Paired Tissue Microarrays in Non–Small Cell Lung Cancer  Chao Li, MD, PhD,
Y-L Chang, MD, C-T Wu, MD, Y-C Lee, MD, PhD 

Y-L Chang, MD, C-T Wu, MD, Y-C Lee, MD, PhD 
The Case of the Missed Chest Radiograph: Bilateral Mammary Gland Metastases Mimicking Multifocal Primary Breast Cancer as the Initial Manifestation of.

The Case of the Missed Chest Radiograph: Bilateral Mammary Gland Metastases Mimicking Multifocal Primary Breast Cancer as the Initial Manifestation of.
VAMP2–NRG1 Fusion Gene is a Novel Oncogenic Driver of Non–Small-Cell Lung Adenocarcinoma  Yeonjoo Jung, PhD, Seunghui Yong, BS, Pora Kim, PhD, Hee-Young.

VAMP2–NRG1 Fusion Gene is a Novel Oncogenic Driver of Non–Small-Cell Lung Adenocarcinoma  Yeonjoo Jung, PhD, Seunghui Yong, BS, Pora Kim, PhD, Hee-Young.
Kunal Mehta, BSE, Erika Moravcikova, PhD, David McFall, AB, James D

Kunal Mehta, BSE, Erika Moravcikova, PhD, David McFall, AB, James D

Similar presentations

Ads by Google