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Volume 125, Issue 4, Pages (October 2003)

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Presentation on theme: "Volume 125, Issue 4, Pages (October 2003)"— Presentation transcript:

1 Volume 125, Issue 4, Pages 1227-1234 (October 2003)
Biliary diversion for progressive familial intrahepatic cholestasis: improved liver morphology and bile acid profile  Amethyst C Kurbegov, Kenneth D.R Setchell, Joel E Haas, Gary W Mierau, Michael Narkewicz, John D Bancroft, Frederick Karrer, Ronald J Sokol  Gastroenterology  Volume 125, Issue 4, Pages (October 2003) DOI: /S (03)

2 Figure 1 Gas chromatography profile of biliary bile acids for patient 1 before and after PEBD. Note the increase in chenodeoxycholic acid/cholic acid ratio after PEBD. Gastroenterology  , DOI: ( /S (03) )

3 Figure 2 Liver biopsy morphology for patient 2 before PEBD. (A) The portal tract is expanded by a combination of fibrosis and mononuclear inflammatory infiltrate. (B) Central vein wall sclerosis is accompanied by swollen hepatocytes showing giant cell transformation (arrow). (H&E; original magnification 260×.) (C) Electron microscopy shows bile canaliculus (BC) distended with coarse granular Byler bile. (Original magnification 8100×.) Gastroenterology  , DOI: ( /S (03) )

4 Figure 3 Liver biopsy morphology of patient 2 at 14 months after PEBD. Note resolution of (A) portal tract inflammation, (B) central vein sclerosis, and cell swelling. (H&E; original magnification 260×.) (C) Electron microscopy shows bile canaliculus (BC) with completely normal appearance. (Original magnification 21,100×.) Gastroenterology  , DOI: ( /S (03) )


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